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Next, to screen the best PROTACs for TYR degradation, we performed western blot (WB) analysis to evaluate the degradation efficiency of TYR and the associated expression level of microphthalmia-associated transcription factor (MITF), a key transcriptional activator in melanin synthesis

Levoglucosan was analysed with high-performance liquid chromatography with pulsed amperometric detection (HPLC-PAD) 59 , metals were characterized by inductively coupled plasma mass spectrometry (ICP-MS) analysis following a protocol close to that in ref

What increasingly determines success is conviction confidence in trial design, data integrity, operational execution, and regulatory alignment from the earliest stages

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Results are gradual and unpredictable